• Bone health
• Women's health
Serving Size: 1 Capsule... %DV...
Strontium (from strontium citrate)... 340.5 mg... †
MBP (a specific basic protein fraction derived from milk)... 20 mg... †
† Daily Value not established
What Is It?
AOR's Advanced Bone Protection + Strontium is an innovative product combining two novel and effective nutrients that work through different mechanisms for a synergistic effect on bone health. These two nutrients are Milk Basic Protein (or MPB™ ) and the mineral strontium. Milk Basic Protein is a nutrient extracted from the whey fraction of milk.
What Does It Do?
Primary Uses: The ingredients in Advanced Bone Protection work synergistically to increase bone health and bone density. MBP has been shown to improve calcium retention by bones. MBP's action involves a specific protein called cystatin C. Cystatin C is able to directly inhibit cysteine protease, an enzyme that releases calcium from bone and digests collagen in the bone matrix. MBP also enhances the activity and collagen production of osteoblasts (cells that build bone) while at the same time suppressing the activity of osteoclasts (cells that break down bone). Strontium, unlike other treatments for degenerative bone conditions such as calcium, vitamin D and anti-resorptive drugs that reduce bone loss, actually increases osteoblast production while decreasing osteoclast production, resulting in increased bone development and decreased bone resorption. Since strontium is similar in molecular structure to calcium, strontium is thought to activate the calcium receptors in the bone, stimulating osteoblast production so that the calcium can be used effectively in bone tissue while inhibiting osteoclast production. Long term strontium supplementation has been shown to continually improve bone density and reduce the risk of osteoporotic fractures.
Who Should Take It?
Advanced Bone Protection + Strontium is good for those with osteoporosis, osteopenia or who are concerned with their general bone health.
SUGGESTED USE (50 years and older): Take 1-2 capsules daily on an empty stomach, at least two hours before or after food, calcium or milk but ensure that daily calcium and vitamin D intake is adequate. Calcium, food and milk products significantly reduce strontium absorption if taken at the same sitting.
Aoe S, et al. A controlled trial of the effect of milk basic protein (MBP) supplementation on bone metabolism in healthy menopausal women. Osteoprosis International. 2005 Dec;16(12):2123-8. Epub 2005 Aug 31.
Aoe S, et al. Controlled Trial of the Effects of Milk Basic Protein (MBP) Supplementation on Bone Metabolism in Healthy Adult Women. Biosci. Biotechnol. Biochem. Vol.65 pp.913-918. 2001.
ATSDR. Toxicological profile for strontium. Atlanta,GA: Agency for toxic substances and disease registry US Dept of Health and Human Services. Public Health Services.2001
Comar,CL , Wasserman, RH and Nold, NM. Strontium-Calcium discrimination factors in the rat. Proc. Sco. Exp. Biol. Med.1950;92:859-863
Dahl, SG et-al. Incorporation and distribution of strontium in bone. Bone.2001;28:446-453
Della Rossa et-al. Absorption and retention of ingested strontium and calcium in beagles as a function of age. Nature.1965;205:197-198
Leeuwenkamp,OR et-al. Human pharmacokinetics of orally administered strontium. Calcif. Tissue Int. 1990;47:136-140
Marie,PJ et-al. Mechanisms of action and therapeutic potential of strontium in bone. Calcif. Tissue Int.2001;69:121-129.
Marie,PJ et-al. Effect of low doses of stable strontium on bone metabolism in rats. Mineral Electrolyte Metab. 1985;11:5-13
Matsumoto, A. Effect of strontium chloride on bone resorption induced by prostaglandin E2 in cultured bone. Arch. Toxicol. 1988;62:240-241
Matsuoka Y, et al. Cystatin C in Milk Basic Protein (MBP) and Its Inhibitory Effect on Bone Resorption in Vitro. Biosci. Biotechnol. Biochem. 2002. Vol.66 pp.2531-2536.
McCaslin FE and Janes, HM. The effect of strontium lactate in the treatment of osteoporosis. Proc. Mayo Clinic. 1959;34:329-334
Shorr, E and Carter, AC. The value of strontium as an adjuvant to calcium in the mineralization of the skeleton in osteoporosis in man. Conference on Metabolic Interactions. Eds. EC Reifenstein Jr.,NY.NY.Pub J Macy Foundation 1950 pp144-154.
Sips, AJAM et-al. Intestinal absorption of strontium chloride in healthy volunteers: pharmacokinetics and reproducibility.Br. J Clin Pharmacol. 1996;41:543-549
Sips, AJAM.Absoption kinetics of strontium and calcium in human and experimental animal. Ph.D Thesis. University of Amsterdam. 1994
Skoryna, SC. Effects of oral supplementation with stable strontium. Can Med J. 1981;125:703-712
Skoryna, SC.Metabolic aspects of the pharmacologic uses of trace elements in human subjects with specific references to stable strontium. Trace Subst. Enviorn Health.1984;18:3-23
Skoryna,SC and Fuskova, M. In: Skoryna, SC ed. Handbook of stable strontium.NY;Plenum:1985.p593-617
Storey,E. Strontium “rickets” bone calcium and strontium changes. Austral.Ann. Med. 1961;10:213-222
Takada Y, et al. Milk Basic Protein Increases Bone Mineral Density and Improves Bone Metabolism In Humans. Nutritional Aspects of Osteoporosis 2nd Ed. (2004); pp. 413-429.
Toba S, et al. Milk Basic Protein Promotes Bone Formation and Suppresses Bone Resorption in Healthy Adult Men. Biosci. Biotechnol. Biochem. Vol.65 pp.1353-1357. 2001
Disclaimer: This content is subject to change. The information is intended to inform and educate; it does not replace the medical evaluation, advice, diagnosis or treatment by a healthcare professional. www.nhpassist.com © 2014 NDAssist Inc. and/or its affiliates. All rights reserved.