Vitamin B3 (Niacinamide) … 2%
Colloidal oatmeal (Avena sativa) … 1%
Mixed tocopherols* (from soy) … 1%
Vitamin B12 (Cyanocobalamin) … 0.07%
*Typical tocopherols profile: Alpha - 0.10%, Beta - 0.02%, Gamma - 0.53%, Delta - 0.22%. Non-medicinal ingredients: purified water, squalane (from olive oil), methylsulfonylmethane (MSM, 8%), polyglyceryl-3 diisostearate, glyceryl behenate, sodium chloride, Epsom salt (magnesium sulfate), potassium sorbate, calcium phosphate dibasic.
Source: Colloidal oatmeal; Mixed tocopherols – soy; Squalane – olive oil; Pharmaceutical synthesis
What Is It?
This unique cream combines scientifically backed topical ingredients including niacinamide, Vitamin B12, colloidal oatmeal, vitamin E and MSM. Designed especially for sensitive skin, Eczema Cream is fragrance-free and contains no artificial colours and as few stabilizers, emulsifiers and non-medicinal ingredients as possible. Eczema Cream contains no sodium lauryl sulfates (SLS), oleates, parabens or mineral oil.
What Does It Do?Primary Uses: Eczema Cream targets and reduces the symptoms of skin irritation and itching associated with eczema. An impaired stratum corneum, the outermost layer of the skin, allows water to escape and irritants in, and is thought to be linked to eczema. Colloidal oatmeal provide a physical barrier to the stratum corneum, limiting dehydration and the infiltration of irritants. Meanwhile, the niacinamide, Vitamin B12, MSM and antioxidants get to work, promoting ceramide synthesis, repairing the corneum stratum, reducing oxidative stress, and reducing cytokine production, all of which increase hydration, decrease inflammation and reduce itching, thus limiting the vicious cycle of skin damage.Secondary Uses: Eczema Cream can also be used to support dry skin since it improves hydration and repair, and evidence also supports the use of niacinamide in rosacea.
Who Should Take It?
People with sensitive or dry skin or who have eczema or rosacea.
Apply to affected skin area(s) as required or as directed by a health care practitioner.
Berardesca E, Cameli N, Cavallotti C, Levy JL, PiÉrard GE, de Paoli Ambrosi G. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008 Mar;7(1):8-14.
Bissett D., Oblong J., Berge C. 2005. Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance. Dermatol Surg; 31:860-865.
Butler J., Chan S., Stevens S., Hanifin J. 1983. Increased Leukocyte Histamine Release with Elevated Cyclic AMP – phosphodiesterase Activity in Atopic Dermatitis. J Allergy Clin. Immunol.; 71(5):490-497.
Draelos Z., Ertel K., Berge C. 2005. Niacinamide-Containing Facial Moisturizer Improves Skin Barrier and Benefits Subjects with Rosacea. Therapeutics for the Clinician; 76(2): 135-41.
Foote J., Moore J., Einspahr J., Saboda K., Kenyon J., Warneke J., Miller R., Goldman R., Xu M., Roe D., Alberts D. 2009. Chemoprevention of Human Actinic Keratoses by Topical DL- α - Tocopherol. Cancer Prev Res; 2(4): 394-400
Fowler J., Nebus J., Wallo W., Eichenfield L. 2012. Colloidal Oatmeal Formulations as Adjunct Treatments in Atopic Dermatitis. Journal of Drugs in Dermatology; 11(7): 804-807
Imokawa G., Abe A., Jin K., Higaki Y., Kawashima M., Hidano A. 1991. Decreased Level of Ceramides in Stratum-Corneum of Atopic-Dermatitis – An Etiologic Factor in Atopic Dry Skin. Journal of Investigative Dermatology; 96(4): 523-526
Irvine A., McLean W., Leung D. 2011. Filaggrin Mutations Associated with Skin and Allergic Diseases. The New England Journal of Medicine; 365:1315-27.
Januchowski R. 2009. Evaluation of Topical Vitamin B12 for the treatment of childhood eczema. The journal of Alternative and Complementary Medicine; 15(4):387-389.
Kimball A., Kaczvinsky J., Li J., Robinson L., Matts P., Berge C., Miyamoto K., Bissett D. 2010. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. British Journal of Dermatology; 162: 435-441.
Kurtz E and Wallo W. 2007. Colloidal Oatmeal: History, Chemistry and Clinical Properties. Journal of Drugs in Dermatology; 6(2):167-170.
Pedrelli V., Lauriola M., Pigatto P. 2011. Clinical Evaluation of Photoprotective effect by a Topical Antioxidants Combination (Tocopherols and Tocotrienols). European Academy of Dermatology and Venereology; 2011 Sep 14.
Sapuntsova S., Lebed'ko O., Schetkina M., Fleyshman M., Kozulin E., Timoshin S. 2010. Status of Free-Radical Oxidation and Proliferation Processes in Patients with Atopic Dermatitis and Lichen Planus. Bulletin of Experimental Biology and Medicine; 150(6): 690-692
Schempp C., Meinke M., Lademann J., Ferrari Y., Brecht T., Gehring W. Topical antioxidants protect the skin from chemical-induces irritation in the repetitive washing test: a placebo-controlled, double-blind study. Contact Dermatitis; 2012 Oct;67(4):234-237.
Seidenari S and Giusti G. 1995. Objective assessment of the skin of children affected by atopic dermatitis: A study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Dermato-Venereologica; 75(6):429-433
Shalita A. and Smith G. Topical Nicotinamide Compared with Clindamycin Gel in the Treatment of Inflammatory Acne Vulgaris. International Journal of Dermatology; 34(6): 434-437
Soma Y., Kashima M., Imaizumi A., Takahama H., Kawakami T., Mizoguchi M. Moisturizing effects of topical nicotinamide on atopic dry skin. The International Society of Dermatology; 44:197-202.
StÜcker M., Memmel U., Hoffmann M., Hartung J., Altmeyer P. 2001. Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis. Dermatology; 203(2):141-7
StÜcker M., Pieck C., Stoerb C., Niendner R., Hartung J., Altmeyer P. 2004. Topical vitamin B12 – a new therapeutic approach in atopic dermatitis – evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial. British Journal of Dermatology; 150: 977-983.
Tanno O., Ota Y., Kitamura N., Katsube T., Inoue S. 2000. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. British Journal of Dermatology; 143:524-531
Tripathi R, Gupta S, Rai S, Mittal PC. Effect of topical application of methylsulfonylmethane (MSM), EDTA on pitting edema and oxidative stress in a double blind, placebo-controlled study. Cell Mol Biol (Noisy-le-grand). 2011 Feb 12;57(1):62-9.
Weinberg B., Chen Y., Jiang N., Beasley B., Salerno J., Ghosh D. 2009. Inhibition of Nitric Oxide Synthase by Cobalamins and Cobinamides. Free Radic Biol Med.; 46(12): 1626–1632
Yamashiki M, Nishimura A, Kosaka Y. 1991. Effects of methylcobalamin (vitamin B12) on in vitro cytokine production of peripheral blood mononuclear cells. J Clin Lab Immunol.; 37(4):173-82.
Zhang M, Wong IG, Gin JB, Ansari NH. Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy. Drug Deliv. 2009 Jul;16(5):243-8.
Disclaimer: This content is subject to change. The information is intended to inform and educate; it does not replace the medical evaluation, advice, diagnosis or treatment by a healthcare professional. www.nhpassist.com © 2014 NDAssist Inc. and/or its affiliates. All rights reserved.