• Neurological health
What Is It?
There are several forms of vitamin B12. Cyanocobalamin is the most common supplement form of B12. Once absorbed, it is converted into hydroxocobalamin, then adenosylcobalamin (the body's storage form of B12 and one of its active coenzyme forms), and then possibly methylcobalamin (the other active coenzyme form of B12). While an adequate intake of methylcobalamin ensures adequate levels of adenosylcobalamin, an adequate intake of other forms of B12 does not ensure adequate levels of methylcobalamin, the form of B12 shown to support the brain and nervous system. The recommended daily intake for vitamin B12 is a mere 2.4 micrograms, although supplementation with much greater amounts can be beneficial even if a deficiency does not exist.
What Does It Do?Primary Uses: High doses of methylcobalamin have been shown to protect the nervous system from toxins, help heal nerve cells and provide nutritional support in neurodegenerative conditions. In humans, supplementation with high doses of methylcobalamin has been shown to provide neurological support in people with degenerative nerve conditions such as Bell's palsy, multiple sclerosis, Lou Gehrig's disease and degenerative spinal conditions.Secondary Uses: Methylcobalamin may also help normalize sleep-wake cycles, providing a better quality sleep for some.
Who Should Take It?
Methylcobalamin is useful for those who have neurological conditions or nerve problems. Vegetarians, elderly people, those suffering from pernicious or megaloblastic anemia, atrophic gastritis, Celiac disease, Crohn's disease or other types of inflammatory gastrointestinal disorders may benefit from high doses of methylcobalamin.
Dissolve 1 lozenge under the tongue first thing in the morning with/without food, or as directed by a qualified health care practitioner.
Jalaludin MA. Methylcobalamin treatment of Bell ‘s palsy. Methods Find Exp Clin Pharmacol. 1995 Oct; 17(8): 539-44.
Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J. Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials inamyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve. 1998 Dec; 21(12): 1775-8.
Kira J, Tobimatsu S, Goto I. Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis. Intern Med. 1994 Feb; 33(2): 82-6.
Mitsuyama Y, Kogoh H. Serum and cerebrospinal fluid vitamin B12 levels in demented patients with CH3-B12 treatment – preliminary study. Jpn J Psychiatry Neurol. 1988 Mar; 42(1): 65-71.
Takahashi K, Okawa M, Matsumoto M, et al. Double-blind test on the efficacy of methylcobalamin on sleep-wake rhythm disorders. Psychiatry Clin Neurosci. 1999 Apr; 53(2): 211-3.
Yagi N, Ishikawa Y, Fukazawa T. The effect of steroid and CH3-vB12 on peripheral facial paralysis. Otol Fukuoaka. 1981; 74(7): 1613.
Yaqub BA, Siddique A, Sulimani R. Effects of methylcobalamin on diabetic neuropathy. Clin Neurol Neurosurg. 1992; 94(2): 105-11.
Disclaimer: This content is subject to change. The information is intended to inform and educate; it does not replace the medical evaluation, advice, diagnosis or treatment by a healthcare professional. www.nhpassist.com © 2014 NDAssist Inc. and/or its affiliates. All rights reserved.