Indications

• Improves calmness and relaxation with daily stress, reduces the negative effects of caffeine consumption, and complements other antistress supplements
• Fast acting, effects can be felt in as little as five minutes and can last from four to six hours
• GABA-Pro uses Pharma GABA, the natural form of GABA which is superior to the synthetic. It is naturally manufactured via a fermentation process that utilizes Lactobacillus hilgardii, the bacterium used to ferment vegetables in the preparing the traditional Korean dish kimchi.
• Gentle and non-addictive with virtually no side effects
• Suitable for vegetarians/vegans

Ingredients

Serving Size: 2 Vegetarian Capsules
Servings per Container: 45

Each Capsule Contains:
Gamma-Aminobutyric Acid (GABA) ... 100 mg
(from 125 mg Pharma GABA™ 80 Complex)

Non-medicinal Ingredients
Rice powder, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant), silica.

Allergens
Contains no artificial colours, preservatives, or sweeteners; no dairy, sugar, wheat, gluten, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Description

Gamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the central nervous system, balancing the excitatory effects of glutamate on neuronal activity. The inhibitory effects of GABA are generally considered to lessen anxiety, relax muscle tension, and have sedative-like effects.1 In addition, conditions such as anxiety, depression, insomnia, and epilepsy have all been associated with low GABA concentration or activity.2,3 GABA has also been shown to cause a significant increase in alpha brain waves compared to control, indicative of a more relaxed state, as well as better concentration. In a clinical trial involving patients with a fear of heights, GABA-Pro was found to increase salivary levels of sIgA while crossing a suspension bridge, as compared to the control group whose salivary IgA levels dropped 35%.4 This is indicative of the stress reducing effect of GABA-Pro.5,6

Increasing GABA activity is also a therapeutic target for many medications used in the treatment of insomnia, often by targeting GABA receptors. This has the effect of decreasing waking, shorten sleep latency, and increasing slow-wave sleep.7,8

Quantity

90 Vegetarian Capsules

Dose

Chew 1–2 tablets 3 times per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 4 weeks.

Potential side effects/Safety

Contraindications
Consult a health care practitioner prior to use if you are pregnant or breastfeeding. Do not use with alcohol. Keep out of reach of children.

Drug Interactions
No known drug interactions have been documented; however a theoretical concern exists for interaction with CNS depressants.

References

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References
1. Gajcy K1, Lochy?nski S, Librowski T. A role of GABA analogues in the treatment of neurological diseases. Curr Med Chem. 2010;17(22):2338-47.
2. Kendell SF, Krystal JH, Sanacora G. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opin Ther Targets. 2005:9:153-168.
3. Nemeroff CB. The role of GABA in the pathophysiology and treatment of anxiety disorders. Psychopharmacol Bull 2003:37:133-146.
4. Abdou AM, Higashiguchi S, Horie K, et al. Relaxation and immunity enhancement effects of gamma aminobutyric acid (GABA) adminisrration in humans. Biofactors 2006;26:201-208.
5. Yoto A1, Murao S, Motoki M, et al. Oral intake of γ -aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks. Amino Acids. 2012 Sep;43(3):1331-7. doi: 10.1007/s00726-011-1206-6.
6. Yang Y, Koh D, Ng V, et al. Self perceived work related stress and the relation with salivary IgA and lysozyme among emergency department nurses. Occup Environ Med. 2002;59(12):836-841.
7. Walsh JK1, Salkeld L, Knowles LJ, et al. Treatment of elderly primary insomnia patients with EVT 201 improves sleep initiation, sleep maintenance, and daytime sleepiness. Sleep Med. 2010 Jan;11(1):23-30. doi: 10.1016/j.sleep.2009.07.012.
8. Lundahl J1, Staner L, Staner C, et al. Short-term treatment with gaboxadol improves sleep maintenance and enhances slow wave sleep in adult patients with primary insomnia. Psychopharmacology (Berl). 2007 Nov;195(1):139-46.