Indications

Benefits
• Supports gut barrier integrity and function
• Protects the gastrointestinal tract from oxidative damage and provides support for a healthy intestinal environment
• Provides a gluten free protein source for those with gluten sensitivities
• Targeted nutrients that help support the flow of bile and keep the bowels moving efficiently
• Excellent multivitamin and mineral supplement for those with nutrient malabsorption
• Low allergy potential, gluten free, and low glycemic load and index

Ingredients

Ingredients

Serving Size: 1 scoop
Servings per Container: 14
Each Scoop (32.4 g) Contains
Vitamins:
Vitamin C (Ascorbic Acid)… 75 mg
Pantothenic Acid (Calcium d-Pantothenate)… 25 mg
Vitamin B6 (Pyridoxine Hydrochloride)… 25 mg
Vitamin E (d-alpha Tocopheryl Acetate)... 25 IU (16.7 mg AT*)
Vitamin B1 (Thiamine Hydrochloride)… 12.5 mg
Vitamin B2 (Riboflavin)… 10 mg
Niacinamide… 6 mg
Beta-Carotene… 4800 IU (2880 mcg)
Folic Acid (Folate)… 250 mcg
Vitamin B12 (Cyanocobalamin)… 100 mcg
Vitamin D3 (Cholecalciferol)… 100 IU (2.5 mcg)
Minerals:
Calcium (Citrate, Sulfate, Dibasic Calcium Phosphate Dihydrate)… 208 mg
Magnesium (Citrate)… 100 mg
Potassium (Citrate)… 100 mg
Phosphorus (Dibasic Calcium Phosphate Dihydrate)… 44 mg
Zinc (Citrate)… 12.5 mg
Chromium (HVP** Chelate)… 50 mcg
Iodine (Potassium Iodide)… 50 mcg
Selenium (HVP** Chelate)… 50 mcg
Molybdenum (Citrate)… 12.5 mcg
Additional Ingredients:
Bifidobacterium longum subsp. longum BB536
(whole cell)… 5 billion cfu***
Organic Sprouted Brown Rice Protein Concentrate (grain) .. 16 g
Soy Lecithin (Glycine max) (seed)… 1500 mg
L-Glutamine… 1000 mg
Fructooligosaccharides (FOS) (Cichorium intybus) (root) .. 560 mg
L-Lysine Hydrochloride… 119 mg
Glycine… 77 mg
N-Acetyl-L-Cysteine… 42 mg
Bromelain (Ananas comosus var. comosus)
(stem)... 37.5 mg (562,500 FCC PU****)
N-Acetylglucosamine… 12.5 mg
Quercetin (Dihydrate)… 12.5 mg
Milk Thistle Powdered Extract (Silybum marianum) (seed)
Standardized to 60% Silymarin… 11 mg
Grape Seed Powdered Extract (Vitis vinifera) (seed)
Standardized to 80% Oligomeric Proanthocyanidins… 11 mg
*AT: Alpha Tocopherol
**HVP: Hydrolyzed Vegetable Protein
***cfu: colony forming units
****FCC: Food Chemical Codex; PU: Papain Unit

Non-Medicinal Ingredients
Microcrystalline cellulose, medium chain triglycerides, organic cane sugar, guar gum, natural flavours (apple, banana, blueberry, raspberry, strawberry), Stevia rebaudiana leaf, lemon oil.

Allergens:
Contains no artificial colours, preservatives, or sweeteners; no dairy, wheat, gluten, yeast, egg, salt, tree nuts, or GMOs. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place. Store in a light-resistant container.

Description

RestorX is a gluten-free formula which contains a number of nutrients known to support the restoration of intestinal permeability, and optimize gut barrier integrity and function. L-glutamine is the primary amino acid source for intestinal cells, and also regulates intercellular junction integrity.1 N-acetyl glucosamine (NAG) provides the substrate for glycosaminoglycan formation, often impaired with increased intestinal permeability.2 Zinc is included, with a deficiency shown to disrupt tight junctions and alter membrane permeability.3

Antioxidants, including vitamins C and E, grape seed extract, milk thistle, and beta carotene, protect the GI from oxidative damage, and provide support for hepatic detoxification of compounds associated with dysbiosis and intestinal dysfunction.4,5,6 Quercetin has been shown to be critical to intestinal integrity, in part by stabilizing mast cells which regulate intestinal function and tight junction integrity.7,8,9 Bifidobacterium longum (patented strain BB536), a probiotic, has been found to prevent damage to intestinal cells and to increase production of tight junction cell proteins, which improves intestinal integrity.10 The use of organic-sprouted brown rice as the gluten-free protein source allows those with celiac disease or gluten sensitivities to safely restore intestinal wall health.

Quantity

450 g Powder

Dose

For Daily Maintenance: Start your day with 1 scoop (32.4 g) mixed as instructed below or as directed by a health care practitioner.

For Intestinal Rejuvenation: 1 scoop (32.4 g) 2 times per day or as directed by a health care practitioner. Take a few hours before or after taking other medications, or as directed by a health care practitioner.

Blend, shake or briskly stir 1 scoop (32.4 g) into 250 ml of purified water or freshly pressed juice (vegetable or fruit). Customize your drink mix by blending 1 scoop (32.4 g) with 250 ml of purified water and 1 cup of fresh or frozen organic berries or other fruit. Stir and drink immediately. For prolonged use, consult a health care practitioner.

Potential side effects/Safety

Contraindications
For adults only. Consult a health care practitioner if you have nausea, fever, vomiting, bloody diarrhea, severe abdominal pain, have kidney stones, or are following a low protein diet. If you have a gastrointestinal lesion/ ulcer, are taking an anticoagulant/blood thinner, anti-inflammatory or antibiotic, or are having surgery, consult a health care practitioner prior to use. Discontinue use and consult a health care practitioner if hypersensitivity/allergy occurs or if symptoms of digestive upset (e.g. nausea, vomiting, diarrhea) occur, worsen, or persist beyond 3 days. Zinc supplementation can cause a copper deficiency. Do not use if you are pregnant or breastfeeding, are taking antibiotics or nitroglycerin, have an immune-compromised condition (e.g. AIDS, lymphoma, patients undergoing long-term corticosteroid treatment). Keep out of reach of children.

Drug Interactions
No known drug interactions.

References

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References
1. Li N, Neu J. Glutamine deprivation alters intestinal tight junctions via a PI3-K/Akt mediated pathway in Caco-2 cells. J Nutr. 2009 Apr;139(4):710-4.
2. Salvatore S, Heuschkel R, Tomlin S, et al. A pilot study of N-acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis, in paediatric chronic inflammatory bowel disease. Aliment Pharmacol Ther.2000 Dec;14(12):1567-79.
3. Amasheh M, Andres S, Amasheh S, et al. Barrier effects of nutritional factors. Ann N Y Acad Sci. 2009 May;1165:267-73.
4. Kiruthiga PV, Shafreen RB, Pandian SK, et al. Silymarin protection against major reactive oxygen species released by environmental toxins: exogenous H2O2 exposure in erythrocytes. Basic Clin Pharmacol Toxicol.2007 Jun;100(6):414-9.
5. Razavi SM1, Gholamin S, Eskandari A, et al. Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia. J Med Food. 2013 Mar;16(3):255-8. doi: 10.1089/jmf.2012.2408.
6. Atkuri KR, N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9.
7. Suzuki T, Hara H. Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr. 2009 May;139(5):965-74.
8. Amasheh M, Schlichter S, Amasheh S, et al. Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells. J Nutr.2008 Jun;138(6):1067-73.
9. Bischoff SC, KrÄmer S. Human mast cells, bacteria, and intestinal immunity. Immunol Rev. 2007 Jun;217:329-37.
10. Takeda Y, Nakase H et al. Upregulation of T-bet and tight junction molecules by Bifidobactrium longum improves colonic inflammation of ulcerative colitis. Inflamm Bowel Dis. 2009 Nov;15(11):1617-8.