Indications

AMPK is a master control mechanism for cellular energy homeostasis. It determines body fat composition and has a significant impact on mitochondrial biogenesis, the diabesity spectrum and life span extension in mice models. Necessary for one of the terminal steps in the electron transport chain in the process of energy (ATP) production). Thus, as a necessary component of mitochondria for the production of energy, CoQ-10 has potential to improve physiologic function in a number of /conditions associated with impaired mitochondrial function. Use for increased oxygenation need in cardiac stress or insufficiency, immune dysfunction, FM, CFS, headaches, high blood pressure, allergies, asthma, diabetes, ulcers, viral infections, periodontal disease, and multiple sclerosis (MS). As an Antioxidant, Cell membrane stabilization, Inhibition of inflammation by modulation of NF-kappaB, Reduces blood pressure in hypertensive patients as effectively as 1-2 drug combination treatment, Benefits pts with CHF or CRF, anti-allergy benefits. CoQ-10 deficiency is common in migraines and supplementation greatly reduces migraine attacks and Headaches 2007;47:73-80.

Ingredients

Thiamin (B1) (as cocarboxylase chloride) 1.5 mg
Riboflavin (B2) (as riboflavin-5-phosphate) 1.7 mg
Niacin (as niacin & niacinamide) 20 mg
Vitamin B6 (as pyridoxal-5-phosphate) 2 mg
Folate (as calcium folinate) 400 mcg
Vitamin B12 (as methylcobalamin) 6 mcg
Biotin 300 mcg Pantothenic acid (as calcium pantothenate) 10 mg
Coenzyme Q10 (emulsified) 100 mg *

Description

ATP Production (Allergies)

Quantity

60 tablets

Dose

One tablet daily as directed by your health care professional.

Potential side effects/Safety

Biotics Research uses no soy byproducts, no artificial flavors or colorants, no propylene glycol, and no detergents or other artificial surfactants in our proprietary emulsification process. As a cellular component, CoQ10 has two primary functions in the body; first, to act in the transfer of electrons as a necessary part of ATP production, and second, to function as an essential antioxidant. CoQ10 participates in all energy processes in the body, and has been termed “the hub around which life processes revolve in the human body.”3 It also plays a vital role in the cellular membrane, functioning in its stability, fluidity and permeability, in addition to stimulating cell growth and inhibiting cell death.4,5,6 In the body there is no means for storage for CoQ10, thus it must be made or replenished on a daily basis. Its synthesis in the cell mitochondria involves a complex 17-step process, which is dependent upon at least seven vitamin cofactors, including riboflavin (vitamin B2), niacin (vitamin B3), vitamin B6, vitamin B12, pantothenic acid (vitamin B5), folic acid, and vitamin C, along with several trace elements. In humans, the highest concentrations of CoQ10 are found in the heart, liver, muscle, kidney and brain. CoQ10 is an organic, nonprotein molecule which is ubiquitous in the cellular matrix. The fact that it is ubiquitous initiated its primary designation, that of ubiquinone. Ubiquinone and ubiquinol, the reduced form of CoQ10, are known as redox pairs, meaning that in the cellular matrix they cycle back and forth. These two entities are rapidly inter-converted, regardless of the form ingested. Of importance to note is that the body naturally produces ubiquinone and not ubiquinol. Human studies utilizing ubiquinol are lacking, thus claims on its superiority are presently invalid. Conversely, CoQ10 or ubiquinone has been utilized in hundreds of clinical studies, which have demonstrated its benefits for cardiovascular health, as well as for numerous other health issues.

References

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Based on a double blind clinical study, daily ingestion of 1 tablet (30 mg) of Biotics Research Corporation's emulsified CoQ10 for 4 weeks was demonstrated to increase plasma CoQ10 levels by 210%, equivalent to 90-100 mg of dry CoQ10. Furthermore, dry CoQ10 powder increased serum levels in only 57% of subjects, while the Biotics Research Corporation emulsified CoQ10 produced an increase in serum CoQ10 levels in 80% of the subjects.1,2 References: 1. Stiles J, Sparks B, Klenda B, Pillors M, Bucci L. Enhanced blood levels of coenzyme Q10 from an emulsified form. Second Symposium on Nutrition and Chiropractic Proceedings. 1989 Apr;15-16. 2. Stiles J, Sparks B, Klenda B, Pillors M, Bucci L. Enhanced uptake in humans of coenzyme Q10 from an emulsified form. Third International Congress of Biomedical Gerontology. June, 1989. 3. Judy WV, Stogsdill WW, Judy DS, Jusy JS. Coenzyme Q10 Facts or Fabrications. 4. Crane FL. Biochemical functions of coenzyme Q10. J Am Coll Nutr. 2001;20:591–598. 5. Niki E. Mechanisms and dynamics of antioxidant action of ubiquinol. Mol Aspects Med. 1997;18:S63–70. doi: 10.1016/S0098-2997(97)00035-6. 6. Jones K, Hughes K, Mischley L, McKenna DJ. Coenzyme Q-10: efficacy, safety, and use. Altern Ther Health Med. 2002;8:42–55. quiz 56,138.