Indications

• Offers a full array of protective compounds from cruciferous vegetables, including I3C, DIM, and sulforaphane
• Provides a unique blend of botanicals that improve estrogen metabolism, shifting away from carcinogenic metabolites
• Supports detoxification of a variety of environmental toxins as well as naturally produced hormones by enhancing phase 1 and phase 2 liver enzymes
• Contains botanicals with potent anti-inflammatory activity
• Suitable for vegetarians/vegans

Ingredients

Each Vegetarian Capsule Contains:
Calcium D-Glucarate (
d
-Glucaric Acid Calcium Salt) : 75 mg
Indole-3-Carbinol (3-Hydroxymethylindole) : 75 mg
Green Tea Extract
(Camellia sinensis)
(leaf) (80% Catechins, 45% EGCG*, < 1% Caffeine) : 50 mg
Tomato Extract
(Lycopersicon esculentum)
(fruit) (5% Lycopene) : 50 mg
Broccoli Powder
(Brassica oleracea var. italica)
(aerial) (0.36% Sulforaphane) : 27.5 mg
DIM (3,3’-Diindolylmethane) : 25 mg
Turmeric Extract
(Curcuma longa)
(rhizome) (95% Curcuminoids) : 25 mg
Milk Thistle Extract
(Silybum marianum)
(seed) (50–60% Silymarin) : 25 mg
Rosemary 6:1 Extract
(Rosmarinus officinalis)
(leaf) : 12.5 mg
* Epigallocatechin-3-gallate

Vegetarian capsule (carbohydrate gum [cellulose ], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.

Description

EstroVantage EM provides a comprehensive formula of plant-based compounds that improve the metabolism of estrogen and its metabolites. Cruciferous vegetables contain a variety of glucosinolates, which some studies have associated with a reduction in cancer incidence when consumed in greater amounts, most likely by causing a shift in metabolism to less carcinogenic estrogen metabolites.
1,2
EstroVantage EM contains indole-3-carbinol (I3C) and its metabolite 3,3’-diindolylmethane (DIM), as well as sulforaphane from broccoli powder, all of which have been linked to lower rates of neoplastic changes and a more favourable estrogen profile.
3-6
Not only do these glucosinolates improve estrogen metabolism, they also reduce inflammation by targeting key signalling molecules, such as Nrf2 and NF- κ B.
7,8

EstroVantage EM also includes other potent plant compounds that reduce inflammation and block carcinogenic pathways. Silymarin, a milk thistle extract, down-regulates gene products involved in the proliferation of tumour cells, along with their invasion, angiogenesis, and metastasis. In addition, it enhances glucuronidation and maintains glutathione levels.
9-11
This unique combination provides green tea polyphenols, lycopene (tomato extract), turmeric and rosemary extracts, as well as calcium D-glucarate, all of which have been shown to favourably shift estrogen metabolism and reduce carcinogenic risk.
12-14
Most recently, a randomized, double-blind, placebo-controlled crossover study demonstrated that taking this formula led to markedly higher urinary levels of the protective 2-OHE < sub > 1 < /sub > estrogen metabolite and lower levels of the more dangerous 16 α -OHE < sub > 1 < /sub > estrogen metabolite in premenopausal women.Most recently, a randomized, double-blind, placebo-controlled crossover study demonstrated that taking this formula led to markedly higher urinary levels of the protective 2-OHE < sub > 1 < /sub > estrogen metabolite and lower levels of the more dangerous 16 α -OHE < sub > 1 < /sub > estrogen metabolite in premenopausal women.
15

Quantity

90 Vegetarian Capsules

Dose

3 capsules once per day with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.

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2026