Indications

• Grape Seed SAP can be used as a systemic anti-inflammatory to reduce formation of inflammatory cytokines and inflammatory mediators;
• Grape Seed SAP can be used to help treat and prevent atherosclerotic plaque;
• Grape Seed SAP is an effective treatment to reduce oxidized LDL;
• Grape Seed SAP can be used as a tool to protect multiple organs from a variety of toxic drugs;
• Grape Seed SAP can be used to help prevent breast cancer caused by low-dose carcinogen exposure;
• Grape Seed SAP is an adjunctive treatment for breast, lung or gastric adenocarcinomas;
• Grape Seed SAP is a powerful antioxidant with better free radical scavenging than vitamins C or E, or beta-carotene.

Ingredients

Each capsule contains:
Grape seed extract (Vitis vinifera) (95% Proanthocyanidins) ... 500 mg

Contains no: Preservatives, artificial flavour or colour, sugar, dairy, starch, wheat, gluten, corn, soy or yeast.

Description

Grape seed extract (GSE) contains proanthocyanidins, which have been demonstrated to exhibit a wide spectrum of pharmacological, therapeutic and chemoprotective properties.(1) Studies have demonstrated that GSE can reduce inflammation by inhibiting the formation of inflammatory cytokines and reducing inflammatory mediators.(2, 3) GSE can ameliorate atherosclerosis by reducing inflammation, decreasing MDA-LDL and by decreasing foam cell formation.(4, 5, 6) GSE has been found to be cytotoxic toward human breast, lung and gastric adenocarcinoma cells.(7) Many pharmaceuticals can damage various organ systems. GSE has been studied and has the ability to protect multiple organs from toxicity caused by drugs or chemicals.(7) GSE is a powerful antioxidant that has a wide range of health benefits and has been shown to have better free radical scavenging ability than vitamins C or E, or beta-carotene. PURITY, CLEANLINESS AND SAFETY Grape Seed SAP has been third party tested to ensure it is free of any heavy metals, pesticides or other impurities. Grape seed extract (GSE) is sourced from the seeds of red grapes, which are known for their high content of proanthocyanidins. Proanthocyanidins have remarkable antioxidant properties and have the ability to reduce oxidative stress and free radical damage. This affords them the ability to protect the cardiovascular system, to reduce inflammation, to be chemoprotective, and to potentially protect us from the progression of several chronic diseases. GSE AND INFLAMMATION A study preformed on mice and rats with experimentallyinduced inflammation demonstrated that proanthocyanidins (PAs) from GSE exerted an anti-inflammatory effect.(2) Animals were dosed at 10 mg/kg proanthocyanidins, which had the effect of inhibiting beta NAG and NOS activity as well as lowering the values of NO, IL 1 β , TNF α and PGE2. The inhibitory effects of the PAs were compared to dexamethasone at 2 mg/kg and found to be superior.(2) Another study preformed on human umbilical vein endothelial cells using 50 100 mcg/ml GSE demonstrated that this dose was effective at reducing inflammation induced by TNF α in the HUVEC.(3) This finding suggests that consumption of GSE may be beneficial for inflammatory atherosclerosis.(3) GSE AND CARDIOVASCULAR HEALTH Atherosclerosis is a condition that affects the arteries, in which fatty plaques develop on the inner arterial wall; this in turn leads to obstructed blood flow.(4) Malondialdehyde-modified LDL (MDA-LDL) is a chemical modification thought to reflect the naturally-occurring oxidation of LDL.(5) It is the oxidized LDL that adheres to the arterial wall. In a human clinical trial on patients with elevated LDL cholesterol, subjects were given either placebo, 200 mg or 400 mg GSE, and lipid values were assessed at 6 and 12 weeks.(6) The placebo group had no change in MDA LDL levels, whereas the group who received 200 mg showed a non-statistically significant decrease in MDA LDL and the group who received 400 mg GSE showed a statistically significant decrease in MDA LDL levels.(6) In a study performed on hamsters (hamsters possess similar lipid profiles to humans), animals were fed a hypercholesterolemic diet, which resulted in foam cell formation in the arteries. Foam cell development is an early marker of atherosclerotic changes. The animals were then supplemented with 50 mg/kg or 100 mg/kg GSE, and the atherosclerosis was reduced by approximately 50% and 63%, respectively.(4) GSE ORGAN PROTECTION FROM PHARMACEUTICALS In this study, GSE was given to animals for 7–10 days prior to drug/chemical exposure, while the control group received no GSE.(8) Experimenters then administered various drugs, including acetaminophen, amiodarone, doxorubicin, cadmium chloride and dimethylnitrosamine. The treatment group was provided almost complete protection as per serum chemistry changes including ALT, blood urea nitrogen and creatine kinase. GSE was able to inhibit both forms of cell death (necrosis and apoptosis) and reduce DNA damage that is typically triggered by these drugs. Upon organ examination, similar patterns to those of the serum analysis were also seen, with there being limited hepatoxicity from acetaminophen, pulmonary toxicity from amiodarone, cardiotoxicity from doxorubicin, nephrotoxicity from cadmium chloride and splenotoxicity from dimethylnitrosamine.(8) The only organ that had only partial protection was brain tissue from damage due to O ethyl S,S dipropyl phosphorodithioate. These results suggest that GSE is a bioavailable agent that provides significant organ protection against a multitude of drug and toxin exposure.(8) GSE AND CANCER Breast cancer is currently the most common cancer that occurs in women. A study was performed using GSE as a preventative measure to protect women from ongoing low-dose carcinogen exposure.(9) The study used a model system and measured both biological and molecular targets and found that GSE was indeed valuable for preventing human breast cell carcinogenesis induced by repeated exposures to low doses of various environmental carcinogens.(9) GSE was found in another study to be a possible adjunctive treatment for breast cancer, as it demonstrated the ability to arrest the cell cycle of the breast cancer cell MCF 7 in the S period.(10) GSE also has the ability to inhibit the proliferation of some colorectal carcinoma cell lines, and was associated with a mechanism that causes apoptosis of the mitochondrial membrane in these cells.(11) Tumour cell migration is the main mechanism by which metastasis occurs. A study examined the ability of GSE to prevent metastasis of nonsmall cell human lung cancer cells. Using an in vitro migration assay, they found that treatment of A549 and H1299 cells with GSPs resulted in a concentration-dependent inhibition of migration of these cells.(12) More human clinical trials need to be performed, but based on current research, GSE could be a useful for both prevention and treatment of several different cancer cell lines.

Quantity

60 capsules per bottle

Dose

Take one capsule daily or as directed by your health care practitioner. Consult a health care
practitioner for use beyond 3 months.

Potential side effects/Safety

Grape seed extract has been studied for both acute and long-term use and has been found to be
safe and not cause any detrimental side effects for doses up to 500 mg/kg/day in vivo.

References

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1. Bagchi D, Ray SD, Patel D, Bagchi M. Protection against drug- and chemical-induced multiorgan
toxicity by a novel IH636 grape seed proanthocyanidin extract. Drugs Exp Clin Res. 2001;27(1):3-15.
2. Li WG, Zhang XY, Wu YJ, Tian X Anti-inflammatory effect and mechanism of proanthocyanidins
from grape seeds. Acta Pharmacol Sin. 2001 Dec;22(12):1117-20.
3. Chao CL, Chang NC, Weng CS, Lee KR, Kao ST, Hsu JC, Ho FM. Grape seed extract ameliorates
tumor necrosis factor- α -induced inflammatory status of human umbilical vein endothelial cells.
Eur J Nutr. 2010 Nov 28. [Epub ahead of print]
4. Vinson JA, Mandarano MA, Shuta DL, Bagchi M, Bagchi D. Beneficial effects of a novel IH636
grape seed proanthocyanidin extract and a niacin-bound chromium in a hamster atherosclerosis
model. Mol Cell Biochem. 2002 Nov;240(1-2):99-103.
5. Amaki T, Suzuki T, Nakamura F, Hayashi D, Imai Y, Morita H, Fukino K, Nojiri T,Kitano S, Hibi N,
Yamazaki T and R Nagai. Circulating malondialdehyde modified LDL is a biochemical risk marker
for coronary artery disease. Heart. 2004 October; 90(10): 1211–1213.
6. Sano A, Uchida R, Saito M, Shioya N, Komori M, Tho Y and N Hashizume. 2007. Beneficial Effects
of Grape Seed Extract on Malondialdehyde-Modified LDL . J Nutr Sci Vitaminol 53: 174-182.
7. Ray S, Bagchi D, Lim PM, Bagchi M, Gross SM, Kothari SC, Preuss HG, Stohs SJ. Acute and
long-term safety evaluation of a novel IH636 grape seed proanthocyanidin extract. Res Commun
Mol Pathol Pharmacol. 2001 Mar-Apr;109(3-4):165-97.
8. Bagchi D, Ray SD, Patel D, Bagchi M Protection against drug- and chemical-induced multiorgan
toxicity by a novel IH636 grape seed proanthocyanidin extract. Drugs Exp Clin Res. 2001;27(1):3-15.
9. Song X, Siriwardhana N, Rathore K, Lin D, Wang HC. Grape seed proanthocyanidin suppression
of breast cell carcinogenesis induced by chronic exposure to combined 4-(methylnitrosamino)-1-
(3-pyridyl)-1-butanone and benzo[a]pyrene. Mol Carcinog. 2010 May;49(5):450-63.
10. Chen C, Liu C, Zhang J, Yang Q, Teng F. Grape seed extract inhibit proliferation of breast cancer
cell MCF-7 and decrease the gene expression of survivin. Zhongguo Zhong Yao Za Zhi. 2009
Feb;34(4):433-7.
11. Hsu CP, Lin YH, Chou CC, Zhou SP, Hsu YC, Liu CL, Ku FM, Chung YC. Mechanisms of
grape seed procyanidin-induced apoptosis in colorectal carcinoma cells. Anticancer Res 2009
Jan;29(1):283-9.
12. Punathil T, Katiyar SK. Inhibition of non-small cell lung cancer cell migration by grape seed
proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and
ERK1/2. Mol Carcinog. 2009 Mar;48(3):232-42.