Indications

Iron SAP provides nutritive support for healthy cellular respiration, red blood cell formation, and increased hemoglobin and plasma ferritin. Iron SAP can reduce the symptoms of iron deficiency anemia and improve markers of iron status.
Iron bound to amino acids for superior nutrition Iron glycinate, also known as iron bis-glycine chelate, is composed of one unit of inorganic iron bound to two glycine molecules that protect it from dietary inhibitors and intestinal interactions in the duodenum thereby increasing bioavailability(1).
All three components are utilized by the body as precursors to hemoglobin, the protein responsible for the delivery of oxygen to peripheral tissues.

Ingredients

Iron Glycinate 30 mg
Succinic acid 100 mg
L-Glycine 100 mg
Vitamin B1 (Thiamine HCl) 5 mg
Vitamin B2 (Riboflavin 5-phosphate) 5 mg
Vitamin B3 (Inositol hexanicotinate) 5 mg
Vitamin B6 (Pyridoxal 5-phosphate) 5 mg
Vitamin B12 (Methylcobalamin) 400 mcg
Folic acid as folate 500 mcg
Copper citrate 1 mg

Description

Iron-deficiency anemia is the most prevalent type of anemia in North America and can cause fatigue, weakness, headaches, and poor concentration. Particularly susceptible are women of childbearing age and pregnant women, children, undernourished labourers, and the very poor. In children, deficiency can result in irreversible impairment of growth and cognitive development, emotional problems, and impaired immune function. Common problems with iron supplementation have included poor bioavailability, extensive inhibition by dietary components (most notably phytates), and gastrointestinal side effects. Iron chelated with the amino acid glycine is more highly absorbable and elicits greater clinical efficacy than other forms while exhibiting minimal digestive discomfort.

Quantity

60 capsules/bottle

Dose

1 capsule daily with a meal or as directed by your physician.
1 capsule provides 30 mg of elemental iron

Potential side effects/Safety

Iron bis-glycinate chelate is Generally Recognized As Safe (GRAS) according to US-FDA guidelines(10)
and has been demonstrated to have a No Observable Adverse Effect Level (NOAEL) of at least 500 mg/kg
body weight in rats(10). Iron bis-glycine chelate has a lower acute oral toxicity than ferrous sulphate(3).
Absorption inversely correlates with iron stores, minimizing the risk of iron overload(7).

References

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Pizarro F, Olivares M, Hertrampf E, Mazariegos DI, Arredondo M, Letelier A, Gidi V. 2002. “Iron bis-glycine chelate competes for the nonheme-iron absorption pathway.” 1. Am J Clin Nutr, 76(3):577-81.
GarcÍa-Casal M., Layrisse M. 2001. “The effect of change in pH on the solubility of iron bis-glycinate chelate and other iron compounds.” 2. Arch Latinoam Nutr, 51(1 Suppl 1):35-6.
Jeppsen R., Borzelleca J. 1999. “Safety evaluation of ferrous bisglycinate chelate.” 3. Food Chem Toxicol, 37(7):723-31.
Hertrampf E., Olivares M. 2004. “Iron amino acid chelates.” 4. Int J Vitam Nutr Res, 74(6):435-43.
Layrisse M., GarcÍa-Casal M., Solano L., BarÓn M., Arguello F., Llovera D., RamÍrez J., Leets I., Tropper E. 2000. “Iron bioavailability in humans from breakfasts enriched with iron bis-glycine chelate, 5. phytates and polyphenols.” J Nutr, 130(9):2195-9. Erratum in: J Nutr, 130(12):3106
Pineda O., Ashmead H. 2001. “Effectiveness of treatment of iron-deficiency anemia in infants and young children with ferrous bis-glycinate chelate.” 6. Nutrition, 17(5):381-4.
Olivares M., Pizarro F., Pineda O., Name J., Hertrampf E., Walter T. 1997. “Milk inhibits and ascorbic acid favors ferrous bis-glycine chelate bioavailability in humans.” 7. J Nutr, 127(7):1407-11.
Pineda O., Ashmead H., Perez J., Ponce-Lemus C. 1994. “Effectiveness of iron amino acid chelate on the treatment of iron deficiency anemia in adolescents.” 8. J Appl Nutr, 46:2-13.
Coplin M., Schuette S., Leichtmann G., Lashner B. 1991. “Tolerability of iron: a comparison of bis-glycino iron II and ferrous sulfate.” 9. Clin Ther, 13(5):606-12
Jeppsen RB. 2001. “Toxicology and safety of Ferrochel and other iron amino acid chelates.” 10. Arch Latinoam Nutr, 51(1 Suppl 1):26-34.