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Back SAMe 400 mg (Pubmed References)

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    • signature-supplements-same-400-mg signature-supplements-same-400-mg
    • Indications
    • Ingredients
    • Description
    • Quantity
    • Dose
    • Safety

    SAMe 400 mg

    Manufacturer: Signature Supplements
    Code:SAME400-VC60
    • Indications
    • Ingredients
    • Description
    • Quantity
    • Dose
    • Safety

    Indications

    Detox and Liver, Musculoskeletal and Connective Tissue, Neurological

    Ingredients

    Each capsule contains:
    SAMe (S-adenosylmethionine) 400 mg

    Description

    S-Adenosylmethionine (SAMe) is a methyl donor and is involved in more than 100 biochemical pathways and specific processes. It is indicated for depression, joint health and liver conditions although other conditions can also be improved with SAMe supplementation.

    Quantity

    60 vcaps

    Dose

    1 serving (1 capsule) 2-4x daily or as directed.

    Potential side effects/Safety

    Bipolar disease, before surgery. Caution in pregnancy. Generally well tolerated. Drug interactions exist. SAMe should be taken on an empty stomach. If nausea or heartburn occur, drinking more water may help. As some individuals notice that SAMe is stimulating, it should be taken earlier in the day to avoid insomnia. SAMe has been associated with hypomania and mania.

    Disclaimer: This content is subject to change. The information is intended to inform and educate; it does not replace the medical evaluation, advice, diagnosis or treatment by a healthcare professional. www.nhpassist.com © 2014 NDAssist Inc. and/or its affiliates. All rights reserved.

    • Related Products: “Signature Supplements” See all (1)

    • Related Products:

      “Signature Supplements”
      See all (1)

    REC109add9e525675

    SAMe 400 mg

    Manufacturer:Signature Supplements
    Code:SAME400-VC60

    Indications

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    Detox and Liver, Musculoskeletal and Connective Tissue, Neurological

    Ingredients

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    SAMe (S-adenosylmethionine) 400 mg

    Quantity

    Notice (8): Trying to access array offset on value of type null [APP/Template/Products/index.ctp, line 2807]
    Code Context
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    		'RECND3209' => 'RECND3209',
    		'REC109add9e523571' => 'REC109add9e523571',
    		'RECMG9783' => 'RECMG9783',
    		'REC109add9e522981' => 'REC109add9e522981',
    		'REC109add9e528242' => 'REC109add9e528242',
    		'REC109add9e527388' => 'REC109add9e527388',
    		'REC109add9e525791' => 'REC109add9e525791',
    		'RECMG11151' => 'RECMG11151',
    		'RECMG11035' => 'RECMG11035',
    		'REC109add9e526714' => 'REC109add9e526714',
    		'REC109add9e526145' => 'REC109add9e526145',
    		'REC109add9e526236' => 'REC109add9e526236',
    		'REC109add9e527155' => 'REC109add9e527155',
    		'RECMG10123' => 'RECMG10123',
    		'RECMG10203' => 'RECMG10203',
    		'REC109add9e528524' => 'REC109add9e528524',
    		'RECND6994' => 'RECND6994',
    		'RECMG9347' => 'RECMG9347'
    	],
    	'keyword' => [
    		(int) 0 => 'hydrangea',
    		(int) 1 => 'atheletes_foot',
    		(int) 2 => 'Gymnema_sylvestre',
    		(int) 3 => 'virus',
    		(int) 4 => 'constipation',
    		(int) 5 => 'deep_vein_thrombosis',
    		(int) 6 => 'Saint_Johns_wort',
    		(int) 7 => 'carthartic',
    		(int) 8 => 'Fiber',
    		(int) 9 => 'steatohepatitis',
    		(int) 10 => 'Metagenics',
    		(int) 11 => '_Inc.',
    		(int) 12 => 'cholelithiasis',
    		(int) 13 => 'Toxicodendron_dermatitis',
    		(int) 14 => 'adrenal_fatigue',
    		(int) 15 => 'URTI',
    		(int) 16 => 'Ginkgo_biloba',
    		(int) 17 => 'hormone_imbalance',
    		(int) 18 => 'hypnotic',
    		(int) 19 => 'plantar_fasciitis',
    		(int) 20 => 'Addisons_disease',
    		(int) 21 => 'urinary_bladder_02',
    		(int) 22 => 'Prairie_Naturals',
    		(int) 23 => 'mercury__toxicity',
    		(int) 24 => 'graves_disease',
    		(int) 25 => 'cholestasis',
    		(int) 26 => 'gallbladder_spasm',
    		(int) 27 => 'hepatitis',
    		(int) 28 => 'Menthol',
    		(int) 29 => 'mouth_ulcers',
    		(int) 30 => 'CoQ10',
    		(int) 31 => 'pseudo_ginseng',
    		(int) 32 => 'Agrimonia_eupatoria',
    		(int) 33 => 'galactooligosaccharides',
    		(int) 34 => 'oak',
    		(int) 35 => 'coenzyme_Q10',
    		(int) 36 => 'buckthorn',
    		(int) 37 => 'Vaccinium_myrtillus',
    		(int) 38 => 'bronchitis',
    		(int) 39 => 'Urticaria',
    		(int) 40 => 'sleeplessness',
    		(int) 41 => 'Inula_helenium',
    		(int) 42 => 'vitamin_B2',
    		(int) 43 => 'Trametes_versicolor',
    		(int) 44 => 'Keratoconjunctivitis_sicca',
    		(int) 45 => 'urinary_tract_infection',
    		(int) 46 => 'gall_bladder_21',
    		(int) 47 => 'food_cravings',
    		(int) 48 => 'Phytolacca_americana',
    		(int) 49 => 'St._Francis_Herb_Farm_Inc.',
    		(int) 50 => 'abscess'
    	]
    ]
    $category_name = 'products'
    $and = 'Signature Supplements'
    $similar_products = [
    	(int) 0 => object(Cake\ORM\Entity) {
    
    		'Record' => [
    			[maximum depth reached]
    		],
    		'[new]' => false,
    		'[accessible]' => [
    			[maximum depth reached]
    		],
    		'[dirty]' => [[maximum depth reached]],
    		'[original]' => [[maximum depth reached]],
    		'[virtual]' => [[maximum depth reached]],
    		'[hasErrors]' => false,
    		'[errors]' => [[maximum depth reached]],
    		'[invalid]' => [[maximum depth reached]],
    		'[repository]' => 'Link'
    	
    	}
    ]
    $clipboard = false
    $brand_products = object(Cake\ORM\Entity) {
    
    	'Record' => [
    		'f00_web_header1' => 'Signature Supplements',
    		'f00_web_header2' => 'Signature Supplements',
    		'f00_displaySub' => 'Suppliers',
    		'f01_header1' => 'Signature Supplements',
    		'f01_header2' => 'Signature Supplements',
    		'f01_header3' => '',
    		'f01_header4' => '',
    		'f01_header5' => '',
    		'f01_header6' => '',
    		'zkp_ID_t' => 'RECMG9679',
    		'zkp_recordID_cn' => '858227',
    		'f03_web_image_URL' => '',
    		'f03_imageURL_t' => '',
    		'f99_hidden' => '/products/signature-supplements'
    	],
    	'[new]' => false,
    	'[accessible]' => [
    		'*' => true
    	],
    	'[dirty]' => [],
    	'[original]' => [],
    	'[virtual]' => [],
    	'[hasErrors]' => false,
    	'[errors]' => [],
    	'[invalid]' => [],
    	'[repository]' => 'Link'
    
    }
    $url_id = []
    $record = object(Cake\ORM\Entity) {
    
    	'id' => (int) 4036,
    	'f00_displaySub' => 'Products &#40;Signature Supplements&#41;',
    	'f00_web_header1' => 'SAMe 400 mg',
    	'f00_web_header2' => 'Signature Supplements',
    	'f00_web_title' => 'Signature Supplements: SAMe 400 mg',
    	'f01_header1' => 'SAMe 400 mg',
    	'f01_header2' => 'Signature Supplements',
    	'f01_header3' => 'SAME400-VC60',
    	'f01_header4' => '',
    	'f01_header5' => '',
    	'f01_header6' => '',
    	'f02_body_NHP_summary' => '',
    	'f02_body1' => 'Detox and Liver&#44; Musculoskeletal and Connective Tissue&#44; Neurological',
    	'f02_body2' => 'S-Adenosylmethionine &#40;SAMe&#41; is a methyl donor and is involved in more than 100 biochemical pathways and specific processes. It is indicated for <a href='/conditions/depression' style='text-decoration: none'>depression</a>&#44; joint health and liver conditions although other conditions can also be improved with SAMe supplementation.',
    	'f02_body3' => 'Each capsule contains:  <br> SAMe &#40;S-adenosylmethionine&#41; 400 mg',
    	'f02_body4' => '60 vcaps',
    	'f02_body5' => '1 serving &#40;1 capsule&#41; 2-4x daily or as directed.',
    	'f02_body6' => 'Bipolar disease&#44; before surgery. Caution in <a href='/conditions/pregnancy' style='text-decoration: none'>pregnancy</a>. Generally well tolerated. Drug interactions exist. SAMe should be taken on an empty stomach. If nausea or <a href='/conditions/heartburn' style='text-decoration: none'>heartburn</a> occur&#44; drinking more water may help. As some individuals notice that SAMe is stimulating&#44; it should be taken earlier in the day to avoid <a href='/conditions/insomnia' style='text-decoration: none'>insomnia</a>. SAMe has been associated with hypomania and mania.',
    	'f02_body7' => '',
    	'f02_body8' => '',
    	'f03_web_image_URL' => '',
    	'f03_web_image_URL_large' => 'signature-supplements-same-400-mg',
    	'f01_header0_web_buy_script' => '',
    	'f03_web_store_link' => '',
    	'f03_imageURL_t' => 'Capsules',
    	'f04_keywordsPaid' => '',
    	'f05_significance_n' => '',
    	'f98_shortURL' => '',
    	'zi_sorter_un' => '',
    	'z_hidden_b' => '0',
    	'z_isFilter_b' => '',
    	'z_locked_b' => '',
    	'f99_hidden' => '/products/signature-supplements/same-400-mg',
    	'zkf_oldID_t' => '',
    	'zkp_ID_t' => 'REC109add9e525675',
    	'zkp_recordID_cn' => '858924',
    	'f001_country' => 'Canada',
    	'f001_vendor' => 'Professional Only',
    	'f03_image1_size_cn' => '',
    	'f04_keywordText_t10' => '',
    	'Matt_exp_webviewer' => null,
    	'SP_foundCount_un' => '1209',
    	'z_log_b' => '1',
    	'za_created_m' => '2017-12-29 21:14:00',
    	'za_creator_t' => 'mgowan',
    	'za_modified_m' => '2025-05-01 11:00:00',
    	'za_modifier_t' => 'mgowan',
    	'za_recordAccess_un' => '2',
    	'zi_count_s' => '1209',
    	'zi_CRN_un' => '699',
    	'zk_0_cn' => '',
    	'zk_1_cn' => '1',
    	'zk_2_cn' => '2',
    	'zt_CHT_um' => '63881694059',
    	'zkp_synonyms_for_keyword' => 'and Detoxification <br> detox <br> detoxifies <br> detoxification <br> detoxification <br> phase&#95;I&#95;detoxification <br> phase&#95;II&#95;detoxification <br> cognitive&#95;support <br> cognitive&#95;support <br> neurologic <br> senility <br> cognition <br> studying <br> cognitive health <br> brain function <br> memory <br> mental decline <br> brain support <br> mental function <br> learning <br> cognitive support <br> cognitive&#95;support <br> brain&#95;function <br> mental&#95;decline <br> cognitive&#95;decline <br> brain&#95;support <br> depression <br> sadness <br> low moods <br> dysthymia <br> seasonal effective disorder <br> &#40;SAD&#41; <br> positive mood <br> elevate moods <br> depression <br> depressed <br> depression <br> dysthymia <br> sadness <br> seasonal&#95;effective&#95;disorder <br> Signature&#95;Supplements&#95;Inc. <br> Signature&#95;Supplements&#95;Inc. <br> Signature Supplements <br> Signature&#95;Supplements&#95;Inc.',
    	'z_meta_title' => 'Signature Supplements - SAMe 400 mg',
    	'z_meta_description' => 'Signature Supplements - SAMe 400 mg used for ',
    	'z_Rank_5000' => '',
    	'z_Rank_1000' => '',
    	'z_Rank_700' => '',
    	'z_Rank_500' => '',
    	'z_Rank_400' => '',
    	'z_Rank_300' => 'Signature&#95;Supplements&#95;Inc. Signature&#95;Supplements&#95;Inc. Signature Supplements Signature&#95;Supplements&#95;Inc.',
    	'z_Rank_200' => '',
    	'z_Rank_150' => 'Detoxification detox detoxifies detoxification detoxification phase&#95;I&#95;detoxification phase&#95;II&#95;detoxification cognitive&#95;support cognitive&#95;support neurologic senility cognition studying cognitive health brain function memory mental decline brain support mental function learning cognitive support cognitive&#95;support brain&#95;function mental&#95;decline cognitive&#95;decline brain&#95;support',
    	'z_Rank_100' => '',
    	'z_Rank_75' => '',
    	'z_Rank_50' => '',
    	'z_Rank_25' => 'depression sadness low moods dysthymia seasonal effective disorder &#40;SAD&#41; positive mood elevate moods depression depressed depression dysthymia sadness seasonal&#95;effective&#95;disorder',
    	'z_Rank_1' => '',
    	'[new]' => false,
    	'[accessible]' => [
    		'*' => true
    	],
    	'[dirty]' => [
    		'f02_body_NHP_summary' => true
    	],
    	'[original]' => [],
    	'[virtual]' => [],
    	'[hasErrors]' => false,
    	'[errors]' => [],
    	'[invalid]' => [],
    	'[repository]' => 'Record'
    
    }
    $settings = [
    	'paypal_email' => 'accounts@ndassist.com',
    	'paypal_url' => 'https://www.paypal.com/cgi-bin/webscr',
    	'paypal_price' => '20.00',
    	'paypal_tax' => '2.60',
    	'paypal_item_name' => 'Purchase NDAssist Access',
    	'paypal_currency_code' => 'CAD',
    	'contact_form_email' => 'info@ndassist.com',
    	'sender_email_address' => 'website@nhpassist.com',
    	'student' => 'student9903',
    	'holistic' => 'cannp99302',
    	'paypal_promo_code_price' => '20.00',
    	'comp_feature_price' => '20.00',
    	'paypal_comp_feature_name' => 'Display/Hide Companies and their Products',
    	'paypal_purchase_name' => 'Purchase NDAssist Herbal Rx application',
    	'item_1' => 'ND- Assist Website Access',
    	'item_2' => 'Herbal Rx Application (Download)'
    ]
    $random_records = [
    	(int) 0 => object(Cake\ORM\Entity) {
    
    		'f00_web_header1' => 'KOOPE Milk Cleanser',
    		'f00_web_header2' => 'KOOPE',
    		'f01_header1' => 'KOOPE Milk Cleanser',
    		'f01_header2' => 'KOOPE',
    		'f01_header3' => 'KPE9201 &#40;150 mL &#41;',
    		'f03_web_image_URL' => '',
    		'zkp_ID_t' => 'REC109add9e528524',
    		'zkp_recordID_cn' => '856653',
    		'f03_imageURL_t' => '',
    		'f99_hidden' => '/products/koope/koope-milk-cleanser-kpe9201-150-ml',
    		'[new]' => false,
    		'[accessible]' => [
    			[maximum depth reached]
    		],
    		'[dirty]' => [[maximum depth reached]],
    		'[original]' => [[maximum depth reached]],
    		'[virtual]' => [[maximum depth reached]],
    		'[hasErrors]' => false,
    		'[errors]' => [[maximum depth reached]],
    		'[invalid]' => [[maximum depth reached]],
    		'[repository]' => 'Record'
    	
    	}
    ]
    $id_list = [
    	'REC109add9e526172' => 'REC109add9e526172',
    	'REC109add9e526115' => 'REC109add9e526115',
    	'REC109add9e526718' => 'REC109add9e526718',
    	'RECMG10561' => 'RECMG10561',
    	'REC109add9e526990' => 'REC109add9e526990',
    	'REC109add9e526168' => 'REC109add9e526168',
    	'RECMG7879' => 'RECMG7879',
    	'REC109add9e526668' => 'REC109add9e526668',
    	'RECMG11542' => 'RECMG11542',
    	'RECMG11043' => 'RECMG11043',
    	'RECMG10130' => 'RECMG10130',
    	'REC109add9e523785' => 'REC109add9e523785',
    	'REC109add9e524763' => 'REC109add9e524763',
    	'REC109add9e526728' => 'REC109add9e526728',
    	'REC109add9e527967' => 'REC109add9e527967',
    	'REC109add9e528584' => 'REC109add9e528584',
    	'REC109add9e524436' => 'REC109add9e524436',
    	'REC109add9e523404' => 'REC109add9e523404',
    	'RECMG11193' => 'RECMG11193',
    	'RECMG10841' => 'RECMG10841',
    	'RECND1467' => 'RECND1467',
    	'REC109add9e525067' => 'REC109add9e525067',
    	'REC109add9e525303' => 'REC109add9e525303',
    	'REC109add9e522611' => 'REC109add9e522611',
    	'REC109add9e526242' => 'REC109add9e526242',
    	'RECND757' => 'RECND757',
    	'REC109add9e526042' => 'REC109add9e526042',
    	'REC109add9e526727' => 'REC109add9e526727',
    	'REC109add9e526102' => 'REC109add9e526102',
    	'RECMG11082' => 'RECMG11082',
    	'RECMG9406' => 'RECMG9406',
    	'RECMG9467' => 'RECMG9467',
    	'RECND3209' => 'RECND3209',
    	'REC109add9e523571' => 'REC109add9e523571',
    	'RECMG9783' => 'RECMG9783',
    	'REC109add9e522981' => 'REC109add9e522981',
    	'REC109add9e528242' => 'REC109add9e528242',
    	'REC109add9e527388' => 'REC109add9e527388',
    	'REC109add9e525791' => 'REC109add9e525791',
    	'RECMG11151' => 'RECMG11151',
    	'RECMG11035' => 'RECMG11035',
    	'REC109add9e526714' => 'REC109add9e526714',
    	'REC109add9e526145' => 'REC109add9e526145',
    	'REC109add9e526236' => 'REC109add9e526236',
    	'REC109add9e527155' => 'REC109add9e527155',
    	'RECMG10123' => 'RECMG10123',
    	'RECMG10203' => 'RECMG10203',
    	'REC109add9e528524' => 'REC109add9e528524',
    	'RECND6994' => 'RECND6994',
    	'RECMG9347' => 'RECMG9347'
    ]
    $keyword = [
    	(int) 0 => 'hydrangea',
    	(int) 1 => 'atheletes_foot',
    	(int) 2 => 'Gymnema_sylvestre',
    	(int) 3 => 'virus',
    	(int) 4 => 'constipation',
    	(int) 5 => 'deep_vein_thrombosis',
    	(int) 6 => 'Saint_Johns_wort',
    	(int) 7 => 'carthartic',
    	(int) 8 => 'Fiber',
    	(int) 9 => 'steatohepatitis',
    	(int) 10 => 'Metagenics',
    	(int) 11 => '_Inc.',
    	(int) 12 => 'cholelithiasis',
    	(int) 13 => 'Toxicodendron_dermatitis',
    	(int) 14 => 'adrenal_fatigue',
    	(int) 15 => 'URTI',
    	(int) 16 => 'Ginkgo_biloba',
    	(int) 17 => 'hormone_imbalance',
    	(int) 18 => 'hypnotic',
    	(int) 19 => 'plantar_fasciitis',
    	(int) 20 => 'Addisons_disease',
    	(int) 21 => 'urinary_bladder_02',
    	(int) 22 => 'Prairie_Naturals',
    	(int) 23 => 'mercury__toxicity',
    	(int) 24 => 'graves_disease',
    	(int) 25 => 'cholestasis',
    	(int) 26 => 'gallbladder_spasm',
    	(int) 27 => 'hepatitis',
    	(int) 28 => 'Menthol',
    	(int) 29 => 'mouth_ulcers',
    	(int) 30 => 'CoQ10',
    	(int) 31 => 'pseudo_ginseng',
    	(int) 32 => 'Agrimonia_eupatoria',
    	(int) 33 => 'galactooligosaccharides',
    	(int) 34 => 'oak',
    	(int) 35 => 'coenzyme_Q10',
    	(int) 36 => 'buckthorn',
    	(int) 37 => 'Vaccinium_myrtillus',
    	(int) 38 => 'bronchitis',
    	(int) 39 => 'Urticaria',
    	(int) 40 => 'sleeplessness',
    	(int) 41 => 'Inula_helenium',
    	(int) 42 => 'vitamin_B2',
    	(int) 43 => 'Trametes_versicolor',
    	(int) 44 => 'Keratoconjunctivitis_sicca',
    	(int) 45 => 'urinary_tract_infection',
    	(int) 46 => 'gall_bladder_21',
    	(int) 47 => 'food_cravings',
    	(int) 48 => 'Phytolacca_americana',
    	(int) 49 => 'St._Francis_Herb_Farm_Inc.',
    	(int) 50 => 'abscess'
    ]
    $type = 'Products &#40;Signature Supplements&#41;'
    $brand_product = false
    $title = 'Signature Supplements - SAMe 400 mg'
    $description = 'Signature Supplements - SAMe 400 mg used for '
    $category = 'Products &#40;Signature Supplements&#41;'
    $breadcumbs = [
    	(int) 0 => '',
    	(int) 1 => 'products',
    	(int) 2 => 'signature-supplements',
    	(int) 3 => 'same-400-mg'
    ]
    $breadcumbs_links = [
    	(int) 0 => ''
    ]
    $sender_email = ''
    $subject = 'SAMe 400 mg'
    $image = 'signature-supplements-same-400-mg'
    $image_Url = 'https://www.nhpassist.com//images/Pictures/signature-supplements-same-400-mg.jpg'
    $manufauturer_url = '/catalogs/view?id=products'
    $imageUrl = 'https://www.nhpassist.com//images/Pictures/.jpg'
    $distributedirectory = '/home/ndassist/nhpassist.com/webroot//images/Pictures/.jpg'
    $_featured_products = object(Cake\ORM\Entity) {
    
    	'Record' => [
    		'f00_web_header1' => 'Signature Supplements',
    		'f00_web_header2' => 'Signature Supplements',
    		'f00_displaySub' => 'Suppliers',
    		'f01_header1' => 'Signature Supplements',
    		'f01_header2' => 'Signature Supplements',
    		'f01_header3' => '',
    		'f01_header4' => '',
    		'f01_header5' => '',
    		'f01_header6' => '',
    		'zkp_ID_t' => 'RECMG9679',
    		'zkp_recordID_cn' => '858227',
    		'f03_web_image_URL' => '',
    		'f03_imageURL_t' => '',
    		'f99_hidden' => '/products/signature-supplements'
    	],
    	'[new]' => false,
    	'[accessible]' => [
    		'*' => true
    	],
    	'[dirty]' => [],
    	'[original]' => [],
    	'[virtual]' => [],
    	'[hasErrors]' => false,
    	'[errors]' => [],
    	'[invalid]' => [],
    	'[repository]' => 'Link'
    
    }
    $urlnew = null
    $product_type = 'Products '
    $similar_products_count = (int) 1
    $flex_active_slide = (int) 0
    $_key = (int) 0
    $params = [
    	(int) 0 => ''
    ]
    include - APP/Template/Products/index.ctp, line 2807
    Cake\View\View::_evaluate() - CORE/src/View/View.php, line 1419
    Cake\View\View::_render() - CORE/src/View/View.php, line 1380
    Cake\View\View::render() - CORE/src/View/View.php, line 880
    Cake\Controller\Controller::render() - CORE/src/Controller/Controller.php, line 796
    Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 126
    Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 94
    Cake\Http\BaseApplication::__invoke() - CORE/src/Http/BaseApplication.php, line 235
    Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
    Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
    Cake\Http\Middleware\CsrfProtectionMiddleware::__invoke() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 104
    Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
    Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
    Cake\Routing\Middleware\RoutingMiddleware::__invoke() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 168
    Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
    Cake\Routing\Middleware\AssetMiddleware::__invoke() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 88
    Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65

    Dose

    1 serving (1 capsule) 2-4x daily or as directed.

    Potential side effects/Safety

    Bipolar disease, before surgery. Caution in pregnancy. Generally well tolerated. Drug interactions exist. SAMe should be taken on an empty stomach. If nausea or heartburn occur, drinking more water may help. As some individuals notice that SAMe is stimulating, it should be taken earlier in the day to avoid insomnia. SAMe has been associated with hypomania and mania.

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