• Glucose metabolism
What Is It?
benaGene™ is stabilized oxaloacetic acid, the world's first novel and natural Krebs cycle intermediate compound that is specifically formulated to be highly stable and bioavailable so that a one-a-day dosage is all that is required. benaGene™ offers the potential of longevity and vitality and is exclusively available in Canada from AOR.
What Does It Do?Primary Uses: Caloric restriction is the only method proven to extend human lifespan and healthspan. benaGene™ is a novel caloric restriction mimetic (CR mimetic), mimicking up to 98% of the changes in the genetic expression of over 350 genes in a similar fashion to caloric restriction.
Secondary Uses: While human trials on benaGene™ 's effects on life extension have not been conducted for obvious reasons, human clinical trials have confirmed both reduction in glucose levels and an improved uptake of glucose without negative side effects. benaGene™ appears to down-regulate pathways that create and store fat. Mitochondrial and cellular DNA damage is also thought to exacerbate aging, and benaGene™ both protects and repairs DNA.
Who Should Take It?
Anyone who is interested in ways to slow down the aging process will want to consider taking beneGene™ . It may also help to balance blood sugar levels in people with imbalances. benaGene™ is a perfect partner for resveratrol supplementation.
Take 1 capsule daily with food, or as directed by a qualified health care practitioner.
Cash A., Modification of the NAD+/NADH Ratio Via Oxaloacetic Acid Supplementation to Mimic Calorie Restriction Metabolic Pathways and Increase Lifespan,Anti-Aging Therapeutics Volume XII, American Academy of Anti-Aging Medicine, December 2010.
Hogan D., et al., (2010) Oxaloacetate Enhances Resistance to Fatigue in In vitro Mouse Soleus Muscle. FACSM Division of Physiology, Department of Medicine, UCSD, La Jolla, CA presented at the American College of Sports Medicine.
Nogueira L., (April 2011) Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle,Division of Physiology, Department of Medicine, UCSD, La Jolla, CA, The Federation of American Societies for Experimental Biology
Williams, D.S., et al.,Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.Aging Cell, 2009.8(6): p. 765-768.
Desagher, S., J. Glowinski, and J. Premont,Pyruvate protects neurons against hydrogen peroxide-induced toxicity.J Neurosci, 1997.17(23): p. 9060-7.
Desagher, S. and J.C. Martinou,Mitochondria as the central control point of apoptosis.Trends Cell Biol, 2000.10(9): p. 369-77.
Bhattacharya, R. and R. Tulsawani,In vitro and in vivo evaluation of various carbonyl compounds against cyanide toxicity with particular reference to alpha-ketoglutaric acid.Drug Chem Toxicol, 2008.31(1): p. 149-61.
O'Donnell-Tormey, J., et al.,Secretion of pyruvate. An antioxidant defense of mammalian cells.J Exp Med, 1987.165(2): p. 500-14.
Puntel, R.L., C.W. Nogueira, and J.B. Rocha,Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro.Neurochem Res, 2005.30(2): p. 225-35.
Puntel, R.L., C.W. Nogueira, and J.B. Rocha,N-methyl-D-aspartate receptors are involved in the quinolinic acid, but not in the malonate pro-oxidative activity in vitro.Neurochem Res, 2005.30(3): p. 417-24.
Yoshikawa, K.,Studies on the anti-diabetic effect of sodium oxaloacetate.Tohoku J Exp Med, 1968.96(2): p. 127-41.
Cash, A.,Oxaloacetic Acid Supplementation as a Mimic of Calorie Restriction.Open Longevity Science, 2009.3: p. 22-27.
Yamamoto, H.A. and P.V. Mohanan,Effect of alpha-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice.Toxicol Lett, 2003.143(2): p. 115-22.
Greer, E.L., et al.,An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.Curr Biol, 2007.17(19): p. 1646-56.
Wood, J.P. and N.N. Osborne,Zinc and energy requirements in induction of oxidative stress to retinal pigmented epithelial cells.Neurochem Res, 2003.28(10): p. 1525-33.
Chang, I., et al.,Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetes.Diabetologia, 2003.46(9): p. 1220-7.
Zlotnik, A., et al.,Brain neuroprotection by scavenging blood glutamate.Exp Neurol, 2007.203(1): p. 213-20.
Farah, I.O.,Differential modulation of intracellular energetics in A549 and MRC-5 cells.Biomed Sci Instrum, 2007.43: p. 110-5.
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